Preheat oven to 350°F. Prepare a 9x5 bread loaf pan with nonstick spray or parchment paper.
In a large bowl, gently whisk flour, spices, baking soda, baking powder, and salt. Add mix-ins (except vanilla) to flour mixture. Toss to evenly coat.
In a separate medium bowl, whisk together fruit/vegetable puree or shreds, buttermilk, brown sugar, oil, eggs, and optional vanilla.
Add liquid ingredients to flour mixture. Using a spatula, fold ingredients until just moistened. Do not overmix.
Pour batter into the prepared bread loaf pan. Bake 50-55 minutes or until slightly golden and a toothpick inserted into the middle comes out clean. Enjoy!